Week 1
Thu, Sep 10
@LARamsDivision
27–7W
SF
Team dossierSan FranciscoNFC West
49ers
12-53rd in division · 2025Lost Divisional Round
Season ledger
Schedule & results
Upcoming season · listed lines are closing references
Week 2
Sun, Sep 20
vsMIADolphins
35–13W
Week 3
Sun, Sep 27
vsARICardinalsDivision
36–30W
Week 4
Sun, Oct 4
vsDENBroncos
4:25 PM ET
-3 · O/U 46.5
Week 5
Sun, Oct 11
@SEASeahawksDivision
4:25 PM ET
Week 6
Mon, Oct 19
vsWASCommanders
8:15 PM ET
Week 7
Sun, Oct 25
@ATLFalcons
1:00 PM ET
Week 9
Sun, Nov 8
vsLVRaiders
4:05 PM ET
Week 10
Sun, Nov 15
@DALCowboys
4:25 PM ET
Week 11
Sun, Nov 22
vsMINVikings
8:20 PM ET
Week 12
Sun, Nov 29
vsSEASeahawksDivision
4:25 PM ET
Week 13
Sun, Dec 6
@NYGGiants
1:00 PM ET
Week 14
Sun, Dec 13
vsLARamsDivision
4:25 PM ET
Week 15
Thu, Dec 17
@LACChargers
8:15 PM ET
Week 16
Sun, Dec 27
@KCChiefs
4:25 PM ET
Week 17
Sun, Jan 3
vsPHIEagles
8:20 PM ET
Week 18
Sun, Jan 10
@ARICardinalsDivision
1:00 PM ET