Week 1
Sun, Sep 13
vsBALRavens
23–41L
IND
Team dossierIndianapolisAFC South
Colts
8-93rd in division · 2025
Season ledger
Schedule & results
Upcoming season · listed lines are closing references
Week 2
Sun, Sep 20
@KCChiefs
30–33OTL
Week 3
Sun, Sep 27
vsHOUTexansDivision
19–17W
Week 4
Sun, Oct 4
@WASCommanders
9:30 AM ET
-3 · O/U 47.5
Week 5
Sun, Oct 11
@PITSteelers
1:00 PM ET
Week 6
Sun, Oct 18
vsTENTitansDivision
1:00 PM ET
Week 7
Sun, Oct 25
@MINVikings
1:00 PM ET
Week 8
Sun, Nov 1
@JAXJaguarsDivision
1:00 PM ET
Week 9
Sun, Nov 8
vsDALCowboys
1:00 PM ET
Week 10
Sun, Nov 15
vsMIADolphins
1:00 PM ET
Week 11
Thu, Nov 19
@HOUTexansDivision
8:15 PM ET
Week 12
Sun, Nov 29
vsNYGGiants
1:00 PM ET
Week 14
Sun, Dec 13
@PHIEagles
1:00 PM ET
Week 15
Sun, Dec 20
@TENTitansDivision
1:00 PM ET
Week 16
Sun, Dec 27
vsCINBengals
1:00 PM ET
Week 17
Sun, Jan 3
@CLEBrowns
1:00 PM ET
Week 18
Sun, Jan 10
vsJAXJaguarsDivision
1:00 PM ET