Week 1
Sun, Sep 13
@HOUTexans
36–31W
BUF
Team dossierBuffaloAFC East
Bills
12-52nd in division · 2025Lost Divisional Round
Season ledger
Schedule & results
Upcoming season · listed lines are closing references
Week 2
Thu, Sep 17
vsDETLions
41–31W
Week 3
Sun, Sep 27
vsLACChargers
24–16W
Week 4
Sun, Oct 4
vsNEPatriotsDivision
1:00 PM ET
-7 · O/U 48.5
Week 5
Mon, Oct 12
@LARams
8:15 PM ET
Week 6
Sun, Oct 18
@LVRaiders
4:25 PM ET
Week 8
Sun, Nov 1
vsBALRavens
1:00 PM ET
Week 9
Mon, Nov 9
@MINVikings
8:15 PM ET
Week 10
Sun, Nov 15
@NYJJetsDivision
1:00 PM ET
Week 11
Sun, Nov 22
vsMIADolphinsDivision
1:00 PM ET
Week 12
Thu, Nov 26
vsKCChiefs
8:20 PM ET
Week 13
Sun, Dec 6
@NEPatriotsDivision
4:25 PM ET
Week 14
Sun, Dec 13
@GBPackers
8:20 PM ET
Week 15
Sat, Dec 19
vsCHIBears
8:20 PM ET
Week 16
Fri, Dec 25
@DENBroncos
4:30 PM ET
Week 17
Sun, Jan 3
@MIADolphinsDivision
1:00 PM ET
Week 18
Sun, Jan 10
vsNYJJetsDivision
1:00 PM ET